NDLI: Leukocytes in glomerular injury

Content Provider	Springer Nature Link
Author	Holdsworth, Stephen R. Tipping, Peter G.
Copyright Year	2007
Abstract	Leukocytes of the innate immune system play a central protective role in immune defense to pathogens but may also mediate injurious inflammatory responses resulting in tissue injury. These leukocytes provide the first rapid cellular defense mechanisms through a limited repertoire of rapid pre-programmed responses, but they are also involved in chronic inflammation and tissue repair. They are directed to sites of pathogen challenge and inflammation by a variety of mechanisms and are activated in response to both exogenous and endogenous stimuli. They do not show the capacity of self–non-self discrimination and memory, which are defining characteristics of the adaptive immune system, although macrophages in particular may show some capacity for differentiation of their effector responses. However, they do play an integral role in adaptive immune responses by their capacity to present antigen, modify T-cell development, and function as effectors of adaptive cell-mediated immunity.
Starting Page	355
Ending Page	374
Page Count	20
File Format	PDF
ISSN	18632297
Journal	Springer Seminars in Immunopathology
Volume Number	29
Issue Number	4
e-ISSN	18632300
Language	English
Publisher	Springer-Verlag
Publisher Date	2007-10-16
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Leukocytes Inflammatory responses T cells Macrophages Glomerulonephritis GN Mast cells Neutrophils Glomerular injury Internal Medicine Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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