NDLI: Genetic control of anti-Sm autoantibody production in NOD congenic mice narrowed to the Idd9.3 region

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Genetic control of anti-Sm autoantibody production in NOD congenic mice narrowed to the Idd9.3 region

Content Provider	Springer Nature Link
Author	Irie, Junichiro Wu, Yuehong Sass, David A. Ridgway, William M.
Copyright Year	2006
Abstract	Anti-Smith (anti-Sm) autoantibodies are directed to proteins in the small-nuclear ribonucleoprotein (snRNP) family and are considered specific for systemic lupus erythematosus (SLE) in both humans and mice. We previously established that NOD.c3c4 mice, carrying B6 and B10 congenic segments from chromosomes 3 to 4 on an nonobese diabetic (NOD) background, and NOD.Idd9R28 mice, carrying a B10 segment on c4 alone, developed significant penetrance of anti-Sm antibody production. Here we determine autoantibody incidence in additional NOD.Idd9 congenic strains and use a congenic mapping approach to narrow the interval necessary for enhanced autoantibody production to a ∼5.6-Mb region containing insulin-dependent diabetes (Idd)9.3. The Idd9.3 interval contains the candidate molecule cluster of differentiation (CD)137, which is a member of the tumor necrosis factor (TNF) receptor superfamily, functions as an inducible costimulator of T cells, and controls T–B interactions. The NOD and B10 CD137 alleles have sequence polymorphisms and different functional effects on T cells; the NOD CD137 allele mediates weaker T cell proliferative responses and decreased interleukin (IL)-2 production after CD137-mediated costimulation. Our work establishes CD137 as a candidate gene for control of autoantibody production in NOD.Idd9.3 congenic mice.
Starting Page	9
Ending Page	14
Page Count	6
File Format	PDF
ISSN	00937711
Journal	Immunogenetics
Volume Number	58
Issue Number	1
e-ISSN	14321211
Language	English
Publisher	Springer-Verlag
Publisher Date	2006-01-27
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	CD137 Autoantibodies Anti-Sm antibodies SLE Nonobese diabetic mouse Congenic mice Cell Biology Allergology Immunology
Content Type	Text
Resource Type	Article
Subject	Genetics Immunology

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Genetic control of anti-Sm autoantibody production in NOD congenic mice narrowed to the Idd9.3 region

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Genetic control of anti-Sm autoantibody production in NOD congenic mice narrowed to the Idd9.3 region