NDLI: Congenic mice reveal genetic epistasis and overlapping disease loci for autoimmune diabetes and listeriosis

Content Provider	Springer Nature Link
Author	Wang, Nancy Elso, Colleen M. Mackin, Leanne Mannering, Stuart I. Strugnell, Richard A. Wijburg, Odilia L. Brodnicki, Thomas C.
Copyright Year	2014
Abstract	The nonobese diabetic (NOD) mouse strain serves as a genomic standard for assessing how allelic variation for insulin-dependent diabetes (Idd) loci affects the development of autoimmune diabetes. We previously demonstrated that C57BL/6 (B6) mice harbor a more diabetogenic allele than NOD mice for the Idd14 locus when introduced onto the NOD genetic background. New congenic NOD mouse strains, harboring smaller B6-derived intervals on chromosome 13, now localize Idd14 to an ~18-Mb interval and reveal a new locus, Idd31. Notably, the B6 allele for Idd31 confers protection against diabetes, but only in the absence of the diabetogenic B6 allele for Idd14, indicating genetic epistasis between these two loci. Moreover, congenic mice that are more susceptible to diabetes are more resistant to Listeria monocytogenes infection. This result co-localizes Idd14 and Listr2, a resistance locus for listeriosis, to the same genomic interval and indicates that congenic NOD mice may also be useful for localizing resistance loci for infectious disease.
Starting Page	501
Ending Page	506
Page Count	6
File Format	PDF
ISSN	00937711
Journal	Immunogenetics
Volume Number	66
Issue Number	7-8
e-ISSN	14321211
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2014-06-07
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Type 1 diabetes Listeria monocytogenes Idd14 Idd31 Listr2 Congenic NOD mice Immunology Human Genetics Gene Function Cell Biology Allergology
Content Type	Text
Resource Type	Article
Subject	Genetics Immunology

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