NDLI: Immune-related, lectin-like receptors are differentially expressed in the myeloid and lymphoid lineages of zebrafish

Content Provider	Springer Nature Link
Author	Panagos, Patoula G. Dobrinski, Kimberly P. Chen, Xianghong Grant, Amanda W. Traver, David Djeu, Julie Y. Wei, Sheng Yoder, Jeffrey A.
Copyright Year	2006
Abstract	The identification of C-type lectin (Group V) natural killer (NK) cell receptors in bony fish has remained elusive. Analyses of the Fugu rubripes genome database failed to identify Group V C-type lectin domains (Zelensky and Gready, BMC Genomics 5:51, 2004) suggesting that bony fish, in general, may lack such receptors. Numerous Group II C-type lectin receptors, which are structurally similar to Group V (NK) receptors, have been characterized in bony fish. By searching the zebrafish genome database we have identified a multi-gene family of Group II immune-related, lectin-like receptors (illrs) whose members possess inhibiting and/or activating signaling motifs typical of Group V NK receptors. Illr genes are differentially expressed in the myeloid and lymphoid lineages, suggesting that they may play important roles in the immune functions of multiple hematopoietic cell lineages.
Starting Page	31
Ending Page	40
Page Count	10
File Format	PDF
ISSN	00937711
Journal	Immunogenetics
Volume Number	58
Issue Number	1
e-ISSN	14321211
Language	English
Publisher	Springer-Verlag
Publisher Date	2006-02-09
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	C-type lectin ITIM Natural killer cells Signaling motifs Cell Biology Allergology Immunology
Content Type	Text
Resource Type	Article
Subject	Genetics Immunology

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