NDLI: Structure and developmental expression of Ikaros in the Mexican axolotl

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Immunogenetics : Volume 50, Issue 3-4, November 1999

Immunogenetics : Volume 50, Issue 1-2, October 1999

Immunogenetics : Volume 49

Immunogenetics : Volume 48

Immunogenetics : Volume 47

Immunogenetics : Volume 46

Immunogenetics : Volume 45

Structure and developmental expression of Ikaros in the Mexican axolotl

Content Provider	Springer Nature Link
Author	Durand, C. Charlemagne, J. Fellah, J. S.
Copyright Year	1999
Abstract	TheIkaros family of transcription factors plays an essential role in hematopoiesis. We report here the structure of cDNA clones encoding two Ikaros isoforms, Ik1 and Ik2, in the Mexican axolotl. The Ik1 cDNA sequence is very similar to that of the rainbow trout, chicken, and mammalian Ik1 sequences. However, a 96 base pair region which encodes the first N-terminal zing finger (F1) is lacking from axolotl Ik1, both in clones from a cDNA library and clones isolated from direct polymerase chain reaction products. A region corresponding to exon 3 is completely absent from the axolotl Ik2 sequence and thus the Ik1 and Ik2 isoforms possess the same number of zinc finger motifs. The structure of these five CC-HH motifs is very well conserved in the axolotl, including the structural deviations from its amino acid consensus composition which are identical in all species analyzed to date. The axolotl Ik1 3′ untranslated region sequence is very long (2538 bp) and contains two UA-rich motifs known as instability determinants and which could play a role in mRNA translational efficiency. Ikaros transcripts are first detected in the ventral blood island of stage 36 embryos, about 24 h before the first heartbeats (late tailbud stage), and then in the major lymphopoietic organs of the developing larvae. In situ hybridization demonstrates that Ikaros transcripts are abundant at the periphery of the thymus lobes, in the presumptive site of early thymocyte differentiation.
Starting Page	336
Ending Page	343
Page Count	8
File Format	PDF
ISSN	00937711
Journal	Immunogenetics
Volume Number	50
Issue Number	5-6
e-ISSN	14321211
Language	English
Publisher	Springer-Verlag
Publisher Date	1999-12-02
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Genetics Immunology

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