NDLI: Allelic diversity at class II DRB1 and DQB loci of the pig MHC (SLA)

Content Provider	Springer Nature Link
Author	Hosokawa Kanai, T. Tanioka, Y. Tanigawa, M. Matsumoto, Y. Ueda, S. Odera, T. Matsumoto, Y.
Copyright Year	1999
Abstract	The loci encoding the β chain of the pig major histocompatibility complex (MHC) class II antigens, SLA-DR and -DQ, have been known to exhibit a remarkable degree of allelic polymorphism. Here, to understand the generation of SLA class II polymorphism, 25 SLA-DRB1 and 24 SLA-DQB genes including newly identified 12 SLA-DRB1 and 7 SLA-DQB genes obtained from miniature pigs were analyzed based on the nucleotide and deduced amino acid sequences. Most of the allelic diversity was attributed to the variable sequences which encode a β1 domain consisting of a β-pleated sheet followed by an α helix. In the β1 domain coding region, there were four GC-rich sequences, which have been considered to involve the intra-exon sequence exchange also in other gene evolutions. The first and second GC-rich sequences were χ-like sequences, which have been shown to be a putative recombination signal, and were stably conserved among SLA-DRB1 and DQB genes. These χ-like sequences identified in SLA-DRB1 and SLA-DQB were found to encode the first turning point of the β-pleated sheet and the boundary between the β-pleated sheet and the α helix. Analysis of clustered sequence variation also suggested intra-exon gene conversions in which the χ-like sequences act as putative breakpoints. In addition to point mutations and selection mechanism, intra-exon gene conversions must be an important mechanism in the generation of allelic polymorphism at the SLA-DRB1 and SLA-DQB.
Starting Page	295
Ending Page	300
Page Count	6
File Format	PDF
ISSN	00937711
Journal	Immunogenetics
Volume Number	50
Issue Number	5-6
e-ISSN	14321211
Language	English
Publisher	Springer-Verlag
Publisher Date	1999-12-02
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Subject	Genetics Immunology

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