NDLI: Molecular evolution of immunoglobulin superfamily genes in primates

Content Provider	Springer Nature Link
Author	Ohtani, Hitoshi Nakajima, Toshiaki Akari, Hirofumi Ishida, Takafumi Kimura, Akiri
Copyright Year	2011
Abstract	Genes of the immunoglobulin superfamily (IgSF) have a wide variety of cellular activities. In this study, we investigated molecular evolution of IgSF genes in primates by comparing orthologous sequences of 249 IgSF genes among human, chimpanzee, orangutan, rhesus macaque, and common marmoset. To evaluate the non-synonymous/synonymous substitution ratio (ω), we applied Bn-Bs program and PAML program. IgSF genes were classified into 11 functional categories based on the Gene Ontology (GO) database. Among them, IgSF genes in three functional categories, immune system process (GO:0002376), defense response (GO:0006952), and multi-organism process (GO:0051704), which are tightly linked to the regulation of immune system had much higher values of ω than genes in the other GO categories. In addition, we estimated the average values of ω for each primate lineage. Although each primate lineage had comparable average values of ω, the human lineage showed the lowest ω value for the immune-related genes. Furthermore, 11 IgSF genes, SIGLEC5, SLAMF6, CD33, CD3E, CEACAM8, CD3G, FCER1A, CD48, CD4, TIM4, and FCGR2A, were implied to have been under positive selective pressure during the course of primate evolution. Further sequence analyses of CD3E and CD3G from 23 primate species suggested that the Ig domains of CD3E and CD3G underwent the positive Darwinian selection.
Starting Page	417
Ending Page	428
Page Count	12
File Format	PDF
ISSN	00937711
Journal	Immunogenetics
Volume Number	63
Issue Number	7
e-ISSN	14321211
Language	English
Publisher	Springer-Verlag
Publisher Date	2011-03-10
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Natural selection Immune system Immunoglobulin domain Comparative genomics CD3 complex Cell Biology Human Genetics Gene Function Allergology Immunology
Content Type	Text
Resource Type	Article
Subject	Genetics Immunology

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