NDLI: Phylogenetic and functional conservation of the NKR-P1F and NKR-P1G receptors in rat and mouse

Content Provider	Springer Nature Link
Author	Kveberg, Lise Dai, Ke Zheng Inngjerdingen, Marit Brooks, Colin G. Fossum, Sigbjørn Vaage, John T.
Copyright Year	2011
Abstract	Two clusters of rat Nkrp1 genes can be distinguished based on phylogenetic relationships and functional characteristics. The proximal (centromeric) cluster encodes the well-studied NKR-P1A and NKR-P1B receptors and the distal cluster, the largely uncharacterized, NKR-P1F and NKR-P1G receptors. The inhibitory NKR-P1G receptor is expressed only by the Ly49s3+ NK cell subset as detected by RT-PCR, while the activating NKR-P1F receptor is detected in both Ly49s3+ and NKR-P1B+ NK cells. The mouse NKR-P1G ortholog is expressed by both NKR-P1D− and NKR-P1D+ NK cells in C57BL/6 mice. The rat and mouse NKR-P1F and NKR-P1G receptors demonstrate a striking, cross-species conservation of specificity for Clr ligands. NKR-P1F and NKR-P1G reporter cells reacted with overlapping panels of tumour cell lines and with cells transiently transfected with rat Clr2, Clr3, Clr4, Clr6 and Clr7 and mouse Clrc, Clrf, Clrg and Clrd/x, but not with Clr11 or Clrb, which serve as ligands for NKR-P1 from the proximal cluster. These data suggest that the conserved NKR-P1F and NKR-P1G receptors function as promiscuous receptors for a rapidly evolving family of Clr ligands in rodent NK cells.
Starting Page	429
Ending Page	436
Page Count	8
File Format	PDF
ISSN	00937711
Journal	Immunogenetics
Volume Number	63
Issue Number	7
e-ISSN	14321211
Language	English
Publisher	Springer-Verlag
Publisher Date	2011-03-16
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Comparative Immunology Killer cell lectin-like receptor NK cells Rodent Cell Biology Human Genetics Gene Function Allergology Immunology
Content Type	Text
Resource Type	Article
Subject	Genetics Immunology

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