NDLI: Evolutionary stability of the immunoglobulin heavy chain variable region gene families in teleost

Content Provider	Springer Nature Link
Author	Andersson, E. Matsunaga, T.
Copyright Year	1998
Abstract	A comparison between related species would allow us to study the evolutionary changes in complex gene families. To investigate the evolution of immunoglobulin VH gene families in lower vertebrates, we compared cDNA VH clones from two related teleost fish species, Arctic charr (Salvelinus alpinus) and rainbow trout (Oncorhynchus mykiss), which are separated from their common ancestor by 12–20 million years (MY). The results showed that randomly isolated charr VH genes could be closely grouped to known VH genes of rainbow trout, suggesting that the VH family structure is stable during 12–20 MY and that the total number of VH families changes only gradually over a longer period. This finding also led us to define eight VH gene families of Arctic charr, designated Salalp VH I, VH II, and so on. The presence of species-specific amino acids suggests that non-reciprocal genetic exchanges (e.g., gene duplication) play an important role in shaping the evolution of the V gene family.
Starting Page	272
Ending Page	277
Page Count	6
File Format	PDF
ISSN	00937711
Journal	Immunogenetics
Volume Number	47
Issue Number	3
e-ISSN	14321211
Language	English
Publisher	Springer-Verlag
Publisher Date	1998-01-22
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Genetics Immunology

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Evolutionary stability of the immunoglobulin heavy chain variable region gene families in teleost