NDLI: Organization of the variable region of the immunoglobulin heavy-chain gene locus of the rat

Content Provider	Springer Nature Link
Author	Hendricks, Jacobus Terpstra, Peter Dammers, Peter M. Somasundaram, Rajesh Visser, Annie Stoel, Maaike Bos, Nicolaas A. Kroese, Frans G. M.
Copyright Year	2010
Abstract	We have mapped and annotated the variable region of the immunoglobulin heavy (IGH) gene locus of the Brown Norway (BN) rat (assembly V3.4; Rat Genomic Sequence Consortium). In addition to known variable region genes, we found 12 novel previously unidentified functional IGHV genes and 1 novel functional IGHD gene. In total, the variable region of the rat IGH locus is composed of at least 353 unique IGHV genes, 21 IGHD genes, and 5 IGHJ genes, of which 131, 14, and 4 are potentially functional genes, respectively. Of all species studied so far, the rat seems to have the highest number of functional IGHV genes in the genome. Rat IGHV genes can be classified into 13 IGHV families based on nucleotide sequence identity. The variable region of the BN rat spans a total length of approximately 4.9 Mb and is organized in a typical translocon organization. Like the mouse, members of the various IGHV gene families are more or less grouped together on the genome, albeit some members of IGHV gene families are found intermingled with each other. In the rat, the largest IGHV gene families are IGHV1, IGHV2, and IGHV5. The overall conclusion is that the genomic organization of the variable region of the rat IGH locus is strikingly similar to that of the mouse, illustrating the close evolutionary relationship between these two species.
Starting Page	479
Ending Page	486
Page Count	8
File Format	PDF
ISSN	00937711
Journal	Immunogenetics
Volume Number	62
Issue Number	7
e-ISSN	14321211
Language	English
Publisher	Springer-Verlag
Publisher Date	2010-05-05
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Immunoglobulin locus Rat Immunoglobulin heavy-chain genes Allergology Gene Function Cell Biology Human Genetics Immunology
Content Type	Text
Resource Type	Article
Subject	Genetics Immunology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Characterization of the torafugu (Takifugu rubripes) immunoglobulin heavy chain gene locus

Organization of the variable region of the immunoglobulin heavy-chain gene locus of the rat

Molecular bases of genetic diversity and evolution of the immunoglobulin heavy chain variable region (IGHV) gene locus in leporids

Cynomolgus macaque (Macaca fascicularis) immunoglobulin heavy chain locus description

Intraclass diversification of immunoglobulin heavy chain genes in the African lungfish

Immunoglobulin genes of the turtles

Organization, complexity and allelic diversity of the porcine (Sus scrofa domestica) immunoglobulin lambda locus

Structure of the catfish IGH locus: analysis of the region including the single functional IGHM gene

Genomic variation in the porcine immunoglobulin lambda variable region

Organization of the variable region of the immunoglobulin heavy-chain gene locus of the rat

Similar Documents

Characterization of the torafugu (Takifugu rubripes) immunoglobulin heavy chain gene locus

Organization of the variable region of the immunoglobulin heavy-chain gene locus of the rat

Molecular bases of genetic diversity and evolution of the immunoglobulin heavy chain variable region (IGHV) gene locus in leporids

Cynomolgus macaque (Macaca fascicularis) immunoglobulin heavy chain locus description

Intraclass diversification of immunoglobulin heavy chain genes in the African lungfish

Immunoglobulin genes of the turtles

Organization, complexity and allelic diversity of the porcine (Sus scrofa domestica) immunoglobulin lambda locus

Structure of the catfish IGH locus: analysis of the region including the single functional IGHM gene

Genomic variation in the porcine immunoglobulin lambda variable region

Organization of the variable region of the immunoglobulin heavy-chain gene locus of the rat