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Conserved sequence elements in K promoters from mice and humans: implications for transcriptional regulation and repertoire expression

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Immunogenetics : Volume 45

Conserved sequence elements in K promoters from mice and humans: implications for transcriptional regulation and repertoire expression

Content Provider	Springer Nature Link
Author	Bemark, M. Liberg, David Leanderson, Tomas
Copyright Year	1998
Abstract	Promoter region sequences of human and mouse Igk-V genes were aligned and found to be conserved for about 200–300 base pairs (bp) within subgroups/families. No promoter similarity was found between IGKV promoters from different human subgroups. Related mouse Igk-V gene families were conserved in the promoter region but no similarity was evident when promoters from unrelated Igk-V gene families were compared. Most of the human IGKV promoter subgroups were shown to have mouse counterparts with a similarity region that extended about 150 bp upstream of the translational start codon. All promoters contained an octamer sequence element. The consensus octamer/decamer sequence was favored but only seven residues within the octamer element were strictly conserved. Furthermore, there was also sequence conservation immediately 3′ of the octamer where either an A or a G residue was conserved. In addition, other DNA elements were also conserved both within the Igk-V subgroups/families and between mouse and human promoters from related subgroups/families. In several of the subgroups/families an E box of the E2A type was conserved 5′ of the octamer and a CCCT element was conserved within the IGKV subgroup II and its related mouse Igk-V families. We conclude from this study that conservation of additional sequence elements besides the octamer is a common feature in Igk-V promoters but that distinct elements are conserved only within a given subgroup/family. Thus, the conservation appears to have operated at the level of function rather than at the level of recognition sequence for defined transcription factors.
Starting Page	183
Ending Page	195
Page Count	13
File Format	PDF
ISSN	00937711
Journal	Immunogenetics
Volume Number	47
Issue Number	3
e-ISSN	14321211
Language	English
Publisher	Springer-Verlag
Publisher Date	1998-01-22
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Genetics Immunology

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