NDLI: Comparative molecular and three-dimensional analysis of the peptide–MHC II binding region in both human and Aotus MHC-DRB molecules confirms their usefulness in antimalarial vaccine development

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Comparative molecular and three-dimensional analysis of the peptide–MHC II binding region in both human and Aotus MHC-DRB molecules confirms their usefulness in antimalarial vaccine development

Content Provider	Springer Nature Link
Author	Patarroyo, M. E. Cifuentes, G. Baquero, J.
Copyright Year	2006
Abstract	A vaccine against malaria is desperately needed, and Aotus monkeys are highly susceptible to experimental infection with malarial parasites. A thorough analysis of this monkey’s immune system molecules was thus undertaken in our institute. Cloning and sequencing, followed by three-dimensional analysis, has revealed high homology with some HLA-DRB1 molecules in terms of their peptide binding region pockets. Molecules such as HLA-DRB103, 11, 08, and HLA-DRB104 are so similar to Aotus MHC-DRB molecules that peptides identified as binding to these molecules and inducing protective immunity in these monkeys could be used in humans without further refinement, while small modifications seem to be needed for those binding to HLA-DRB107, HLA-DRB115, 16, and HLA-DRB1*10-like molecules, making this New World monkey an excellent model for tailor-made vaccine development, especially against malaria.
Starting Page	598
Ending Page	606
Page Count	9
File Format	PDF
ISSN	00937711
Journal	Immunogenetics
Volume Number	58
Issue Number	7
e-ISSN	14321211
Language	English
Publisher	Springer-Verlag
Publisher Date	2006-06-22
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Malaria Aotus MHC-DRB P. falciparum 1H-NMR MHC II–peptide–TCR complex Cell Biology Allergology Immunology
Content Type	Text
Resource Type	Article
Subject	Genetics Immunology

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