NDLI: Polymorphism, haplotype composition, and selection in the Mhc-DRB of wild baboons

Content Provider	Springer Nature Link
Author	Huchard, Elise Weill, Mylene Cowlishaw, Guy Raymond, Michel Knapp, Leslie A.
Copyright Year	2008
Abstract	General patterns of organization in the major histocompatibility complex (MHC) have been successfully explained by the model of birth-and-death evolution, but understanding why certain MHC genes are maintained together into specific haplotypes remains challenging. The haplotype configurations of the functionally important class II DR region have been described in few primates and display important interspecific variability with respect to the extent of allelic variation, the number of loci and/or combinations of loci present. Understanding the evolutionary mechanisms driving such variation is conditional upon characterizing haplotypes in new species and identifying the selective pressures acting on haplotypes. This study explores the variability of haplotype configurations in the Mhc-DRB region (exon 2) for the first time in wild non-human primates, chacma baboons (Papio ursinus). Paur-DRB haplotypes were characterized through segregation studies and linkage disequilibrium. 23 Paur-DRB sequences and 15 haplotype configurations were identified in 199 animals. The Paur-DRB exon 2 is shown to be subjected to intense positive selection and frequent recombination. An approach recently developed for human vaccine studies was used to classify Paur-DRB sequences into supertypes, based on the physico-chemical properties of amino acids that are positively selected, thus most probably involved in antigen recognition. Sequences grouped into the same supertype (thus presumably sharing antigen-binding affinities) are non-randomly distributed within haplotypes, leading to an increased individual diversity of supertypes. Our results suggest that selection favoring haplotypes with complementary sets of DRB supertypes shapes functionally tuned haplotypes in this natural baboon population.
Starting Page	585
Ending Page	598
Page Count	14
File Format	PDF
ISSN	00937711
Journal	Immunogenetics
Volume Number	60
Issue Number	10
e-ISSN	14321211
Language	English
Publisher	Springer-Verlag
Publisher Date	2008-08-05
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Major histocompatibility complex Primates Haplotypes Polymorphism Papio ursinus Allergology Cell Biology Gene Function Human Genetics Immunology
Content Type	Text
Resource Type	Article
Subject	Genetics Immunology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Major Histocompatibility Complex class IIB polymorphism in an ancient Spanish breed

Variation analysis and gene annotation of eight MHC haplotypes: The MHC Haplotype Project

Characterisation of MHC class II DRB genes in the northern tree shrew (Tupaia belangeri)

Lineage pattern, trans-species polymorphism, and selection pressure among the major lineages of feline Mhc-DRB peptide-binding region

Discovery of novel MHC-class I alleles and haplotypes in Filipino cynomolgus macaques (Macaca fascicularis) by pyrosequencing and Sanger sequencing : Mafa-class I polymorphism

Duplication polymorphism at MHC class II DRB1 locus in the wild boar (Sus scrofa)

Polymorphism and selection in the major histocompatibility complex DRA and DQA genes in the family Equidae

Molecular genotype identification of the Gallus gallus major histocompatibility complex

Study of cynomolgus monkey (Macaca fascicularis) Mhc DRB gene polymorphism in four populations

Polymorphism, haplotype composition, and selection in the Mhc-DRB of wild baboons

Similar Documents

Major Histocompatibility Complex class IIB polymorphism in an ancient Spanish breed

Variation analysis and gene annotation of eight MHC haplotypes: The MHC Haplotype Project

Characterisation of MHC class II DRB genes in the northern tree shrew (Tupaia belangeri)

Lineage pattern, trans-species polymorphism, and selection pressure among the major lineages of feline Mhc-DRB peptide-binding region

Discovery of novel MHC-class I alleles and haplotypes in Filipino cynomolgus macaques (Macaca fascicularis) by pyrosequencing and Sanger sequencing : Mafa-class I polymorphism

Duplication polymorphism at MHC class II DRB1 locus in the wild boar (Sus scrofa)

Polymorphism and selection in the major histocompatibility complex DRA and DQA genes in the family Equidae

Molecular genotype identification of the Gallus gallus major histocompatibility complex

Study of cynomolgus monkey (Macaca fascicularis) Mhc DRB gene polymorphism in four populations

Polymorphism, haplotype composition, and selection in the Mhc-DRB of wild baboons