NDLI: Two Polymorphic Residues Account for the Differences in DNA Binding and Transcriptional Activation by NF-κB Proteins Encoded by Naturally Occurring Alleles in Nematostella vectensis

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Two Polymorphic Residues Account for the Differences in DNA Binding and Transcriptional Activation by NF-κB Proteins Encoded by Naturally Occurring Alleles in Nematostella vectensis

Content Provider	Springer Nature Link
Author	Wolenski, Francis S. Chandani, Sushil Stefanik, Derek J. Jiang, Ning Chu, Emma Finnerty, John R. Gilmore, Thomas D.
Copyright Year	2011
Abstract	The NF-κB family of transcription factors is activated in response to many environmental and biological stresses, and plays a key role in innate immunity across a broad evolutionary expanse of animals. A simple NF-κB pathway is present in the sea anemone Nematostella vectensis, an important model organism in the phylum Cnidaria. Nematostella has previously been shown to have two naturally occurring NF-κB alleles (Nv-NF-κB-C and Nv-NF-κB-S) that encode proteins with different DNA-binding and transactivation abilities. We show here that polymorphic residues 67 (Cys vs. Ser) and 269 (Ala vs. Glu) play complementary roles in determining the DNA-binding activity of the NF-κB proteins encoded by these two alleles and that residue 67 is primarily responsible for the difference in their transactivation ability. Phylogenetic analysis indicates that Nv-NF-κB-S is the derived allele, consistent with its restricted geographic distribution. These results define polymorphic residues that are important for the DNA-binding and transactivating activities of two naturally occurring variants of Nv-NF-κB. The implications for the appearance of the two Nv-NF-κB alleles in natural populations of sea anemones are discussed.
Starting Page	325
Ending Page	336
Page Count	12
File Format	PDF
ISSN	00222844
Journal	Journal of Molecular Evolution
Volume Number	73
Issue Number	5-6
e-ISSN	14321432
Language	English
Publisher	Springer-Verlag
Publisher Date	2011-12-25
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	NF-κB Nematostella Polymorphism Evolution DNA binding Transactivation Plant Sciences Cell Biology Microbiology Animal Genetics and Genomics Evolutionary Biology Plant Genetics & Genomics
Content Type	Text
Resource Type	Article
Subject	Genetics Molecular Biology Ecology, Evolution, Behavior and Systematics

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