NDLI: Expert consensus on an in vitro approach to assess pulmonary fibrogenic potential of aerosolized nanomaterials

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Expert consensus on an in vitro approach to assess pulmonary fibrogenic potential of aerosolized nanomaterials

Archives of Toxicology : Volume 90, Issue 6, June 2016

Archives of Toxicology : Volume 89

Archives of Toxicology : Volume 87

Archives of Toxicology : Volume 83

Archives of Toxicology : Volume 75

Expert consensus on an in vitro approach to assess pulmonary fibrogenic potential of aerosolized nanomaterials

Content Provider	Springer Nature Link
Author	Clippinger, Amy J. Ahluwalia, Arti Allen, David Bonner, James C. Casey, Warren Castrava, Vincent David, Raymond M. Halappanavar, Sabina Hotchkiss, Jon A. Jarabek, Annie M. Maier, Monika Polk, William Rothen Rutishauser, Barbara Sayes, Christie M. Sayre, Phil Sharma, Monita Stone, Vicki
Copyright Year	2016
Abstract	The increasing use of multi-walled carbon nanotubes (MWCNTs) in consumer products and their potential to induce adverse lung effects following inhalation has lead to much interest in better understanding the hazard associated with these nanomaterials (NMs). While the current regulatory requirement for substances of concern, such as MWCNTs, in many jurisdictions is a 90-day rodent inhalation test, the monetary, ethical, and scientific concerns associated with this test led an international expert group to convene in Washington, DC, USA, to discuss alternative approaches to evaluate the inhalation toxicity of MWCNTs. Pulmonary fibrosis was identified as a key adverse outcome linked to MWCNT exposure, and recommendations were made on the design of an in vitro assay that is predictive of the fibrotic potential of MWCNTs. While fibrosis takes weeks or months to develop in vivo, an in vitro test system may more rapidly predict fibrogenic potential by monitoring pro-fibrotic mediators (e.g., cytokines and growth factors). Therefore, the workshop discussions focused on the necessary specifications related to the development and evaluation of such an in vitro system. Recommendations were made for designing a system using lung-relevant cells co-cultured at the air–liquid interface to assess the pro-fibrogenic potential of aerosolized MWCNTs, while considering human-relevant dosimetry and NM life cycle transformations. The workshop discussions provided the fundamental design components of an air–liquid interface in vitro test system that will be subsequently expanded to the development of an alternative testing strategy to predict pulmonary toxicity and to generate data that will enable effective risk assessment of NMs.
Starting Page	1769
Ending Page	1783
Page Count	15
File Format	PDF
ISSN	03405761
Journal	Archives of Toxicology
Volume Number	90
Issue Number	7
e-ISSN	14320738
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2016-04-27
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Inhalation toxicity Multi-walled carbon nanotubes MWCNTs In vitro testing strategies Regulatory risk assessment Pulmonary fibrosis Pharmacology/Toxicology Occupational Medicine/Industrial Medicine Environmental Health Biomedicine general
Content Type	Text
Resource Type	Report
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology

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