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Archives of Toxicology : Volume 90, Issue 6, June 2016

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Diesel exhaust: current knowledge of adverse effects and underlying cellular mechanisms

Content Provider	Springer Nature Link
Author	Steiner, Sandro Bisig, Christoph Petri Fink, Alke Rothen Rutishauser, Barbara
Copyright Year	2016
Abstract	Diesel engine emissions are among the most prevalent anthropogenic pollutants worldwide, and with the growing popularity of diesel-fueled engines in the private transportation sector, they are becoming increasingly widespread in densely populated urban regions. However, a large number of toxicological studies clearly show that diesel engine emissions profoundly affect human health. Thus the interest in the molecular and cellular mechanisms underlying these effects is large, especially concerning the nature of the components of diesel exhaust responsible for the effects and how they could be eliminated from the exhaust. This review describes the fundamental properties of diesel exhaust as well as the human respiratory tract and concludes that adverse health effects of diesel exhaust not only emerge from its chemical composition, but also from the interplay between its physical properties, the physiological and cellular properties, and function of the human respiratory tract. Furthermore, the primary molecular and cellular mechanisms triggered by diesel exhaust exposure, as well as the fundamentals of the methods for toxicological testing of diesel exhaust toxicity, are described. The key aspects of adverse effects induced by diesel exhaust exposure described herein will be important for regulators to support or ban certain technologies or to legitimate incentives for the development of promising new technologies such as catalytic diesel particle filters.
Starting Page	1541
Ending Page	1553
Page Count	13
File Format	PDF
ISSN	03405761
Journal	Archives of Toxicology
Volume Number	90
Issue Number	7
e-ISSN	14320738
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2016-05-10
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Diesel engines Diesel particles Ultrafine particles Lung cells Adverse effects Pharmacology/Toxicology Occupational Medicine/Industrial Medicine Environmental Health Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology

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Diesel exhaust: current knowledge of adverse effects and underlying cellular mechanisms

Diesel exhaust: current knowledge of adverse effects and underlying cellular mechanisms

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Diesel exhaust: current knowledge of adverse effects and underlying cellular mechanisms

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Diesel exhaust: current knowledge of adverse effects and underlying cellular mechanisms

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Diesel exhaust: current knowledge of adverse effects and underlying cellular mechanisms