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| Content Provider | Springer Nature Link |
|---|---|
| Author | Tanus, Joanna Snini, Selma P. Khoury, Rhoda Canlet, Cécile Pinton, Philippe Lippi, Yannick Alassane Kpembi, Imourana Gauthier, Thierry Khoury, André Atoui, Ali Zhou, Ting Lteif, Roger Oswald, Isabelle P. Puel, Olivier |
| Copyright Year | 2016 |
| Abstract | Patulin is the main mycotoxin contaminating apples. During the brewing of alcoholic beverages, this mycotoxin is degraded to ascladiol, which is also the last precursor of patulin. The present study aims (1) to characterize the last step of the patulin biosynthetic pathway and (2) to describe the toxicity of ascladiol. A patE deletion mutant was generated in Penicillium expansum. In contrast to the wild strain, this mutant does not produce patulin but accumulates high levels of E-ascladiol with few traces of Z-ascladiol. This confirms that patE encodes the patulin synthase involved in the conversion of E-ascladiol to patulin. After purification, cytotoxicities of patulin and E- and Z-ascladiol were investigated on human cell lines from liver, kidney, intestine, and immune system. Patulin was cytotoxic for these four cell lines in a dose-dependent manner. By contrast, both E- and Z-ascladiol were devoid of cytotoxicity. Microarray analyses on human intestinal cells treated with patulin and E-ascladiol showed that the latter, unlike patulin, did not alter the whole human transcription. These results demonstrate that E- and Z-ascladiol are not toxic and therefore patulin detoxification strategies leading to the accumulation of ascladiol are good approaches to limit the patulin risk. |
| Starting Page | 2455 |
| Ending Page | 2467 |
| Page Count | 13 |
| File Format | |
| ISSN | 03405761 |
| Journal | Archives of Toxicology |
| Volume Number | 91 |
| Issue Number | 6 |
| e-ISSN | 14320738 |
| Language | English |
| Publisher | Springer Berlin Heidelberg |
| Publisher Date | 2016-12-02 |
| Publisher Place | Berlin, Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Ascladiol Patulin synthase Penicillium expansum patE gene Cytotoxicity Microarray analysis Pharmacology/Toxicology Occupational Medicine/Industrial Medicine Environmental Health Biomedicine |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology |
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