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| Content Provider | Springer Nature Link |
|---|---|
| Author | Huang, Wan Chen Chen, Shu Ting Chang, Wei Chiao Chang, Kwang Yu Chang, Wen Chang Chen, Ben Kuen |
| Copyright Year | 2010 |
| Abstract | Aryl hydrocarbon receptor nuclear translocator (ARNT) binds to other basic helix-loop-helix Per/ARNT/Sim (bHLH-PAS) proteins to form functional transcriptional complexes in order to regulate specific biological pathways. Here, we report a novel mechanism that upon EGF treatment, ARNT associated with non-bHLH-PAS transcription factors, c-Jun/Sp1, and regulated gene expression, through forming a c-Jun/ARNT/Sp1 complex and binding to the Sp1 site of the gene promoter. EGF-induced promoter activity and the mRNA level of 12(S)-lipoxygenase as well as the association between c-Jun and Sp1 were reduced by ARNT knockdown. Notably, dominant negative c-Jun mutant, TAM-67, blocked ARNT-mediated 12(S)-lipoxygenase expression, demonstrating that c-Jun was responsible for the transcriptional activation. Moreover, ARNT knockdown also inhibited other EGF-induced c-Jun/Sp1 mediated gene expression, such as p21WAF1/CIP1. Our results reveal a novel mechanism by which ARNT acts as a modulator to bridge the c-Jun/Sp1 interaction and plays a role in EGF-mediated gene expression under normoxic conditions. |
| Starting Page | 3523 |
| Ending Page | 3533 |
| Page Count | 11 |
| File Format | |
| ISSN | 1420682X |
| Journal | Cellular and Molecular Life Sciences |
| Volume Number | 67 |
| Issue Number | 20 |
| e-ISSN | 14209071 |
| Language | English |
| Publisher | SP Birkhäuser Verlag Basel |
| Publisher Date | 2010-05-28 |
| Publisher Place | Basel |
| Access Restriction | Subscribed |
| Subject Keyword | Epidermal growth factor (EGF) Aryl hydrocarbon receptor nuclear translocator (ARNT) Gene expression c-Jun/Sp1 Protein–DNA interaction Biochemistry Life Sciences Biomedicine general Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Molecular Biology Molecular Medicine Pharmacology Cellular and Molecular Neuroscience |
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