NDLI: Molecular aspects of cyclophilins mediating therapeutic actions of their ligands

Content Provider	Springer Nature Link
Author	Galat, Andrzej Bua, Jacqueline
Copyright Year	2010
Abstract	Cyclosporine A (CsA) is an immunosuppressive cyclic peptide that binds with a high affinity to 18 kDa human cyclophilin-A (hCyPA). CsA and its several natural derivatives have some pharmacological potential in treatment of diverse immune disorders. More than 20 paralogues of CyPA are expressed in the human body while expression levels and functions of numerous ORFs encoding cyclophilin-like sequences remain unknown. Certain derivatives of CsA devoid of immunosuppressive activity may have some potential in treatments of Alzheimer diseases, Hepatitis C and HIV infections, amyotrophic lateral sclerosis, congenital muscular dystrophy, asthma and various parasitic infections. Here, we discuss structural and functional aspects of the human cyclophilins and their interaction with various intra-cellular targets that can be under the control of CsA or its complexes with diverse cyclophilins that are selectively expressed in different cellular compartments. Some molecular aspects of the cyclophilins expressed in parasites invading humans and causing diseases were also analyzed.
Starting Page	3467
Ending Page	3488
Page Count	22
File Format	PDF
ISSN	1420682X
Journal	Cellular and Molecular Life Sciences
Volume Number	67
Issue Number	20
e-ISSN	14209071
Language	English
Publisher	SP Birkhäuser Verlag Basel
Publisher Date	2010-07-04
Publisher Place	Basel
Access Restriction	Subscribed
Subject Keyword	Cyclophilin PPIase Cyclosporine A Immunophilin Immunosuppression Biochemistry Life Sciences Biomedicine general Cell Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology Molecular Medicine Pharmacology Cellular and Molecular Neuroscience

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Molecular aspects of cyclophilins mediating therapeutic actions of their ligands

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Molecular aspects of cyclophilins mediating therapeutic actions of their ligands