NDLI: Potential role for IL-23 in hepatic ischemia/reperfusion injury

Content Provider	Springer Nature Link
Author	Husted, T. L. Blanchard, J. Schuster, R. Shen, H. Lentsch, A. B.
Copyright Year	2006
Abstract	IL-12 and IL-23 are related cytokines that share a p40 subunit. Our previous studies identified IL-12 as a primary initiator of the cytokine cascade induced after hepatic ischemia/reperfusion. Because those studies were conducted prior to the discovery of IL-23, it is not clear whether IL-12 or IL-23 is the relevant cytokine in this response. The current studies show that the antibodies used in our original study cross-react with IL-23. We also found that both IL-12 p35 and IL-23 p19 mRNA are expressed rapidly in the liver after ischemia/reperfusion. Finally, isolated Kupffer cells produced TNFα in response to IL-23, but not IL-12, suggesting that IL-23 may be the relevant initiator of the hepatic inflammatory response to ischemia/reperfusion.
Starting Page	177
Ending Page	178
Page Count	2
File Format	PDF
ISSN	10233830
Journal	Inflammation Research
Volume Number	55
Issue Number	5
e-ISSN	1420908X
Language	English
Publisher	Birkhäuser-Verlag
Publisher Date	2006-01-01
Publisher Place	Basel
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	IL-23 IL-12 inflammation liver Kupffer cells Pharmacology/Toxicology Dermatology Neurology Rheumatology Immunology Allergology
Content Type	Text
Resource Type	Article
Subject	Pharmacology Immunology

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Potential role for IL-23 in hepatic ischemia/reperfusion injury