NDLI: Earlier onset of neutrophil-mediated inflammation in the ultraviolet-exposed skin of mice deficient in myeloperoxidase and NADPH oxidase

Content Provider	Springer Nature Link
Author	Komatsu, J. Koyama, H. Maeda, N. Aratani, Y.
Copyright Year	2006
Abstract	This study examined the role of neutrophil-derived reactive oxygen species (ROS) in neutrophil recruitment into ultraviolet B (UVB)-exposed skin of mice.Mouse dorsal skin was irradiated with UVB (600 mJ/cm2). Accumulation of neutrophils within the inflammatory sites was observed histochemically. Keratinocyte-derived chemokine (KC) and macrophage inflammatory protein 2 (MIP-2) were quantified, and in vivo chemotaxis of neutrophils toward KC and MIP-2 was examined.UVB exposure of mice deficient in myeloperoxidase (MPO), NADPH oxidase, or both, caused skin neutrophil infiltration peaking at 60, 48, and 48 h, respectively, which was earlier than the 72-h peak in wild-type mice. MIP-2 level was higher in mutant than wild-type mice. Mutant neutrophils produced more MIP-2 in vitro. Neutrophil migration toward a localized source of KC was higher in mutant than wild type mice. NADPH oxidase deficiency had a greater effect on migration than MPO deficiency.These results suggest that ROS produced by neutrophils regulate expression of MIP-2 and migration of neutrophils toward KC. This may explain the earlier infiltration of mutant neutrophils in response to UVB.
Starting Page	200
Ending Page	206
Page Count	7
File Format	PDF
ISSN	10233830
Journal	Inflammation Research
Volume Number	55
Issue Number	5
e-ISSN	1420908X
Language	English
Publisher	Birkhäuser-Verlag
Publisher Date	2006-01-01
Publisher Place	Basel
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Inflammation Myeloperoxidase NADPH oxidase Neutrophil Ultraviolet Pharmacology/Toxicology Dermatology Neurology Rheumatology Immunology Allergology
Content Type	Text
Resource Type	Article
Subject	Pharmacology Immunology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Severe neutrophil-mediated lung inflammation in myeloperoxidase-deficient mice exposed to zymosan

Myeloperoxidase deficiency in mice exacerbates lung inflammation induced by nonviable Candida albicans

Two circulating neutrophil populations in acute inflammation in mice

SH3 domain-mediated interactions involving the phox components of the NADPH oxidase

Posters: Skin Inflammation

Focus Session 10: Skin Inflammation and Wound Healing

Neutrophil recruitment in mast cell-dependent inflammation: inhibitory mechanisms of glucocorticoids

Kallikrein-mediated activation of PARs in inflammation and nociception

Cytokine-Mediated Regulation of Inflammation and Immune Response

Earlier onset of neutrophil-mediated inflammation in the ultraviolet-exposed skin of mice deficient in myeloperoxidase and NADPH oxidase

Similar Documents

Severe neutrophil-mediated lung inflammation in myeloperoxidase-deficient mice exposed to zymosan

Myeloperoxidase deficiency in mice exacerbates lung inflammation induced by nonviable Candida albicans

Two circulating neutrophil populations in acute inflammation in mice

SH3 domain-mediated interactions involving the phox components of the NADPH oxidase

Posters: Skin Inflammation

Focus Session 10: Skin Inflammation and Wound Healing

Neutrophil recruitment in mast cell-dependent inflammation: inhibitory mechanisms of glucocorticoids

Kallikrein-mediated activation of PARs in inflammation and nociception

Cytokine-Mediated Regulation of Inflammation and Immune Response

Earlier onset of neutrophil-mediated inflammation in the ultraviolet-exposed skin of mice deficient in myeloperoxidase and NADPH oxidase