NDLI: Optimal intervention time of vagal stimulation attenuating myocardial ischemia/reperfusion injury in rats

Content Provider	Springer Nature Link
Author	Wang, Qiang Li, Rui Ping Xue, Fu Shan Wang, Shi Yu Cui, Xin Long Cheng, Yi Liu, Gao Pu Liao, Xu
Copyright Year	2014
Abstract	To determine the optimal intervention time of the vagal stimulation (VS) attenuating myocardial ischemia/reperfusion injury (IRI).One hundred and twenty male SD rats were randomly allocated into six groups: sham group, IRI group, the VS performed at 15 min of ischemia (VSI15) group, the VS performed immediately before reperfusion (VSR0) group, the VS performed at 30 min of reperfusion (VSR30) group, and the VS performed at 60 min of reperfusion (VSR60) group. Rats in each group were further allocated into subgroups A and B. In each group, the hemodynamics and ventricular arrhythmias were continuously observed. In the subgroup A, serum inflammatory cytokine levels were tested, and infarct size was assessed. In the subgroup B, myocardial inflammatory cytokine levels in both ischemic and non-ischemic regions were assayed.As compared to the IRI, VSR0, VSR30 and VSR60 groups, infarct size, serum HMGB-1 and ICAM-1 levels at 120 min of reperfusion, myocardial HMGB-1, IL-1 and IL-6 levels in non-ischemic region, myocardial ICAM-1 level in ischemic region were all significantly decreased in the VSI15 group. Compared with the IRI group, myocardial IL-10 levels in both ischemic and non-ischemic regions were significantly increased in the VSI15 group. Compared to the IRI, VSR0, VSR30 and VSR60 groups, incidence and score of ventricular arrhythmia during initial reperfusion were significantly decreased in the VSI15 group.The VS performed at 15 min of ischemia provides the best protection against myocardial IRI. Also, early modulation on inflammatory responses caused by myocardial IRI may contribute to this best cardioprotection.
Starting Page	987
Ending Page	999
Page Count	13
File Format	PDF
ISSN	10233830
Journal	Inflammation Research
Volume Number	63
Issue Number	12
e-ISSN	1420908X
Language	English
Publisher	Springer Basel
Publisher Date	2014-10-08
Publisher Place	Basel
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Ischemia reperfusion injury Vagal stimulation Optimal intervention time Cardioprotection Inflammation Immunology Pharmacology/Toxicology Rheumatology Allergology Dermatology Neurology
Content Type	Text
Resource Type	Article
Subject	Pharmacology Immunology

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