NDLI: Lansiumamide B and SB-204900 isolated from Clausena lansium inhibit histamine and TNF-α release from RBL-2H3 cells

Content Provider	Springer Nature Link
Author	Matsui, Takuya Ito, Chihiro Furukawa, Hiroshi Okada, Tadashi Itoigawa, Masataka
Copyright Year	2013
Abstract	Mast cells play a central role in allergic and chronic inflammation. Extracts from Clausena lansium (Lour.) Skeels (Rutaceae) possess many pharmacological effects including anti-inflammatory, anti-oxidant, anti-cancer, and anti-trichomonal activities. In addition, the leaves and fruit are used in Chinese folk medicine. We have isolated and identified four known cinnamamides from this plant: lansiumamide C, lansamide I, lansiumamide B, and SB-204900. However, the biological activities of these compounds are not yet understood. The purpose of this paper is to clarify the pharmacological effects of these compounds on mast cells.We measured inflammatory molecules in A23187-stimulated rat basophilic leukemia cells (RBL-2H3) treated with these compounds using HPLC, ELISA, and immunoblotting methods. In addition, some signaling molecules were investigated by immunoblotting.Lansamide I, lansiumamide B, and SB-204900 significantly decreased histamine release. Furthermore, lansiumamide B- and SB-204900-treated cells also reduced the protein and/or mRNA levels of TNF-α. SB-204900 markedly suppressed the phosphorylation of p38 MAPK.Our findings suggest that lansiumamide B and SB-204900 attenuate mast-cell-induced inflammation.
Starting Page	333
Ending Page	341
Page Count	9
File Format	PDF
ISSN	10233830
Journal	Inflammation Research
Volume Number	62
Issue Number	3
e-ISSN	1420908X
Language	English
Publisher	SP Birkhäuser Verlag Basel
Publisher Date	2013-01-17
Publisher Place	Basel
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Clausena lansium SB-204900 Mast cell Histamine Pro-inflammatory cytokine Immunology Pharmacology/Toxicology Rheumatology Allergology Dermatology Neurology
Content Type	Text
Resource Type	Article
Subject	Pharmacology Immunology

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