NDLI: Analysis of procalcitonin and CRP concentrations in serum of patients with chronic spontaneous urticaria

Content Provider	Springer Nature Link
Author	Kasperska Zajac, A. Grzanka, A. Machura, E. Mazur, B. Misiolek, M. Czecior, E. Kasperski, J. Jochem, J.
Copyright Year	2012
Abstract	Our previous findings showed the importance of analysing the peripheral markers of acute phase response (APR) activation, C-reactive protein (CRP) and IL-6 in the context of urticaria activity and severity. However, these biomarkers do not reliably differentiate between APR to infectious and the disease severity.In order to investigate a possible association between the immune-inflammatory activation markers CRP and procalcitonin (PCT).Serum PCT and CRP concentrations were measured in patients with CU of varying severity as well as in healthy subjects.Serum PCT and CRP concentrations were significantly increased in more severe CU patients when compared to healthy controls and mild CU, and within the CU population there was a significant correlation between concentrations of PCT and CRP. Serum PCT concentrations remained within normal ranges in most CU patients and were only slightly elevated in some severe CU cases.PCT serum concentration may be only slightly elevated in some cases of severe CU. Upregulation of PCT synthesis accompanied by parallel changes in CRP concentration reflects a low-grade systemic inflammatory response in CU. PCT should be considered as a better marker than CRP to distinguish between APR to infection and an active non-specific urticarial inflammation.
Starting Page	309
Ending Page	312
Page Count	4
File Format	PDF
ISSN	10233830
Journal	Inflammation Research
Volume Number	62
Issue Number	3
e-ISSN	1420908X
Language	English
Publisher	SP Birkhäuser Verlag Basel
Publisher Date	2012-12-04
Publisher Place	Basel
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Procalcitonin Chronic urticaria Acute phase response C-reactive protein Immunology Pharmacology/Toxicology Rheumatology Allergology Dermatology Neurology
Content Type	Text
Resource Type	Article
Subject	Pharmacology Immunology

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