NDLI: Toll-Like Receptors in Human Papillomavirus Infection

Content Provider	Springer Nature Link
Author	Zhou, Qiang Zhu, Kejian Cheng, Hao
Copyright Year	2013
Abstract	Infection with human papillomaviruses (HPVs) often causes cutaneous benign lesions, cervical cancer, and a number of other tumors. The mechanisms of host immune system to prevent and control HPV infection still remain poorly understood. Toll-like receptors (TLRs) are specific pattern recognition molecules that bind to microbial components to trigger innate immunity and direct adaptive immunity in the face of immunological danger. TLRs have been established to play an essential role in sensing and initiating antiviral immune responses. Recent accumulating evidence demonstrated that HPVs modulate TLR expression and interfere with TLR signaling pathways, leading to persistent viral infection and carcinogenesis. This review summarizes current knowledge on the roles of TLR during HPV infection, focusing on TLR recognition, modulation of TLR expression and signaling, regulatory receptors involved in TLR signaling, and cross-talk of TLRs with antimicrobial peptides. Immunotherapeutic strategies based on TLR agonists have emerged to be one of the novel promising avenues in treatment of HPV-associated diseases in the future.
Starting Page	203
Ending Page	215
Page Count	13
File Format	PDF
ISSN	0004069X
Journal	Archivum Immunologiae et Therapiae Experimentalis
Volume Number	61
Issue Number	3
e-ISSN	16614917
Language	English
Publisher	SP Birkhäuser Verlag Basel
Publisher Date	2013-02-24
Publisher Place	Basel
Access Restriction	Subscribed
Subject Keyword	TLR HPV Innate immunity Adaptive immunity TLR agonist Immunology Pharmacology/Toxicology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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