NDLI: Anti-CCL25 Antibody Prolongs Skin Allograft Survival by Blocking CCR9 Expression and Impairing Splenic T-Cell Function

Content Provider	Springer Nature Link
Author	Li, Jie Xiong, Tao Xiao, Ruijing Xiong, Ali Chen, Jie Altaf, Ehtisham Zheng, Yingcheng Zhu, Guoguo He, Yuling Tan, Jinquan
Copyright Year	2013
Abstract	Chemokines, by virtue of their ability to recruit immune cells into allografts, play critical roles in acute transplantation rejection. CCR9 and its ligand, CCL25, is one of the key regulators of thymocyte migration and maturation in normal and inflammatory conditions. Moreover, several studies have revealed that high expression of CCR9 and CCL25 participated in many kinds of diseases. However, the role of CCR9 in allograft rejection is still unclear. In this study, we established a murine skin transplantation model of acute rejection. Our findings showed that the proportion of CCR9-expressing T cells was significantly increased in the spleen of allotransplanted mice compared with syngeneic transplantation. Furthermore, expression of CCL25 in allograft was similarly increased. Neutralization of CCL25 by intravenous injection of anti-CCL25 monoclonal antibody significantly prolonged skin allograft survival, decreased the number of infiltrating cells, and simultaneously suppressed the chemotactic ability and the proliferation of the splenic T cells in response to allogeneic antigens. Finally, blockade of CCL25 also diminished the secretion of IFN-γ by splenic T cells. These studies indicated that CCR9/CCL25 was involved in acute transplantation rejection and anti-CCL25 strategies might be useful in preventing acute rejection.
Starting Page	237
Ending Page	244
Page Count	8
File Format	PDF
ISSN	0004069X
Journal	Archivum Immunologiae et Therapiae Experimentalis
Volume Number	61
Issue Number	3
e-ISSN	16614917
Language	English
Publisher	SP Birkhäuser Verlag Basel
Publisher Date	2013-03-02
Publisher Place	Basel
Access Restriction	Subscribed
Subject Keyword	CCR9 CCL25 Transplantation Rejection Immunology Pharmacology/Toxicology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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