NDLI: Expanding and converting regulatory T cells: a horizon for immunotherapy

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Archivum Immunologiae et Therapiae Experimentalis : Volume 57, Issue 2, April 2009

Archivum Immunologiae et Therapiae Experimentalis : Volume 57, Issue 1, February 2009

Archivum Immunologiae et Therapiae Experimentalis : Volume 56

Archivum Immunologiae et Therapiae Experimentalis : Volume 55

Archivum Immunologiae et Therapiae Experimentalis : Volume 54

Expanding and converting regulatory T cells: a horizon for immunotherapy

Content Provider	Springer Nature Link
Author	Khattar, Mithun Chen, Wenhao Stepkowski, Stanislaw M.
Copyright Year	2009
Abstract	The human immune system is a myriad of diverse cellular populations, each contributing to maintaining an effective and optimal immune response against infectious agents. It is important to maintain a “self-check” in the immune system so that responses do not go haywire, leading to the development of autoimmune diseases. Regulatory/suppressor T (Treg) cells are a specialized subpopulation of T cells that suppress the activation, expansion, and function of other T cells, thereby maintaining homeostasis through a fine balance between reactivity to foreign and self antigens. Tregs are characterized by surface expression of interleukin (IL)-2 receptor α chain (CD25) and intracellular expression of forkhead box protein P3 (FoxP3). There are at least two important functional populations of Treg cells, namely natural Treg (nTreg), which are continuously derived from the thymus, and induced Treg (iTreg), which are converted from naive T cells. The development and function of both nTreg and iTreg cells are regulated by several factors, such as antigen T-cell receptor, co-stimulatory receptors (i.e., cytotoxic T lymphocyte-associated antigen, or CTLA-4), and cytokines (IL-2, IL-10, and tumor growth factor-β, or TGF-β). In addition, the TGF-β inhibitor ALK5, retinoid acid, and rapamycin influence the expansion of nTreg cells and the conversion of iTreg cells in vitro and in vivo. The heightening of Treg expansion may be harnessed to therapeutic methods for the treatment of autoimmune diseases and the induction of transplantation tolerance.
Starting Page	199
Ending Page	204
Page Count	6
File Format	PDF
ISSN	0004069X
Journal	Archivum Immunologiae et Therapiae Experimentalis
Volume Number	57
Issue Number	3
e-ISSN	16614917
Language	English
Publisher	SP Birkhäuser Verlag Basel
Publisher Date	2009-05-29
Publisher Place	Basel
Access Restriction	Subscribed
Subject Keyword	nTreg iTreg FoxP3 expansion conversio Pharmacology/Toxicology Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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