Loading...
Please wait, while we are loading the content...
Similar Documents
P38MAPK-dependent phosphorylation and degradation of SRC-3/AIB1 and RARalpha-mediated transcription.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Gianní, Maurizio Parrella, Edoardo Raska, Ivan Gaillard, Emilie Nigro, Elisa A. Gaudon, Claudine Garattini, Enrico Rochette-Egly, Cécile |
| Copyright Year | 2006 |
| Abstract | Nuclear retinoic acid (RA) receptors (RARs) activate gene expression through dynamic interactions with coregulators in coordination with the ligand and phosphorylation processes. Here we show that during RA-dependent activation of the RARalpha isotype, the p160 coactivator pCIP/ACTR/AIB-1/RAC-3/TRAM-1/SRC-3 is phosphorylated by p38MAPK. SRC-3 phosphorylation has been correlated to an initial facilitation of RARalpha-target genes activation, via the control of the dynamics of the interactions of the coactivator with RARalpha. Then, phosphorylation inhibits transcription via promoting the degradation of SRC-3. In line with this, inhibition of p38MAPK markedly enhances RARalpha-mediated transcription and RA-dependent induction of cell differentiation. SRC-3 phosphorylation and degradation occur only within the context of RARalpha complexes, suggesting that the RAR isotype defines a phosphorylation code through dictating the accessibility of the coactivator to p38MAPK. We propose a model in which RARalpha transcriptional activity is regulated by SRC-3 through coordinated events that are fine-tuned by RA and p38MAPK. |
| Starting Page | 1 |
| Ending Page | 1 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://pdfs.semanticscholar.org/fb5f/1011697e79fb2b1511f6dbe2021ebad0bb2e.pdf |
| Alternate Webpage(s) | http://emboj.embopress.org/content/embojnl/25/4/739.full.pdf |
| Alternate Webpage(s) | http://embojnl.embopress.org/content/embojnl/25/4/739.full.pdf |
| PubMed reference number | 16456540v1 |
| Volume Number | 25 |
| Issue Number | 4 |
| Journal | The EMBO journal |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Activation action Cell Differentiation process Gene Expression Immunoglobulin Isotypes Ligands Promotion (action) Refractory anemia with ringed sideroblasts Retinoic Acid Receptor Alpha, human Transcription, Genetic Tretinoin facilitation steroid receptor coactivator AIB1 |
| Content Type | Text |
| Resource Type | Article |
