NDLI: The proliferating cell nuclear antigen regulates retinoic acid receptor transcriptional activity through direct protein

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The proliferating cell nuclear antigen regulates retinoic acid receptor transcriptional activity through direct protein–protein interaction

Content Provider	Semantic Scholar
Author	Lardeux, Virginie Lefebvre, Philippe
Copyright Year	2005
Abstract	Retinoic acid receptors (RARs) interact, in a ligand-dependent fashion, with many coregulators that participate in a wide spectrum of biological responses, ranging from embryonic development to cellular growth control. The transactivating function of these ligand-inducible transcription factors reside mainly, but not exclusively, in their ligand-binding domain (AF2), which recruits or dismiss coregulators in a ligand-dependent fashion. However, little is known about AF2-independent function(s) of RARs. We have isolated the proliferating cell nuclear antigen (PCNA) as a repressor of RAR transcriptional activity, able to interact with an AF2-crippled RAR. The N-terminus of PCNA interacts directly with the DNA-binding domain of RAR, and PCNA is recruited to a retinoid-regulated promoter in intact cells. This interaction affects the transcriptional response to retinoic acid in a promoter-specific manner, conferring an unanticipated role to PCNA in transcriptional regulation. Our findings also suggest a role for RAR as a factor coordinating DNA transcription and repair.
Starting Page	4311
Ending Page	4321
Page Count	11
File Format	PDF HTM / HTML
PubMed reference number	16055921v1
Volume Number	33
Journal	Nucleic acids research
Alternate Webpage(s)	https://www.scienceopen.com/document_file/b4d8f525-530f-4de4-ade8-2511c72e8bfd/PubMedCentral/b4d8f525-530f-4de4-ade8-2511c72e8bfd.pdf
Language	English
Access Restriction	Open
Subject Keyword	Antigens, Nuclear Embryonic Development Ligand Binding Domain Ligands PCNA gene Proliferating Cell Count Proliferating Cell Nuclear Antigen Refractory anemia with ringed sideroblasts Retinoic Acid Receptor Retinoids TRANSCRIPTION FACTOR Thioctic Acid Transcription Repressor/Corepressor Transcription, Genetic Transcriptional Regulation Tretinoin cell growth
Content Type	Text
Resource Type	Article

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