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MK-801, a non-competitive antagonist of NMDA receptor, prevents methamphetamine-induced decrease of striatal dopamine uptake sites in the rat striatum
| Content Provider | Semantic Scholar |
|---|---|
| Author | Muraki, Akira Koyama, Tsukasa Nakayama, Makoto Ohmori, Tetsuro Yamashita, Itaru |
| Copyright Year | 1992 |
| Abstract | We investigated the effects of MK-801, a non-competitive antagonist of NMDA receptor, on methamphetamine-induced decrease in dopamine (DA) uptake sites in the rat striatum. Repeated administrations of an escalating dose of methamphetamine (2.5, 5, 7.5, 10 mg/kg s.c. x2, every other day for a week) produced decreased DA uptake sites assayed by binding with [3H]GBR 12935 in the striatum. Co-administration of MK-801 and methamphetamine significantly prevented the methamphetamine-induced decrease in striatal [3H]GBR 12935 binding. Administration of MK-801 alone did not affect [3H]GBR 12935 binding. These results suggest that some neurochemical effects of methamphetamine may be mediated via mechanism involving excitatory amino acids. |
| Starting Page | 39 |
| Ending Page | 42 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0304-3940(92)90642-K |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/030439409290642K |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/030439409290642K?dgcid=api_sd_search-api-endpoint |
| PubMed reference number | 1353257 |
| Alternate Webpage(s) | https://doi.org/10.1016/0304-3940%2892%2990642-K |
| Journal | Medline |
| Volume Number | 136 |
| Journal | Neuroscience Letters |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
