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The non-competitive NMDA receptor antagonist (+)MK-801 counteracts the long-lasting attenuation of the hypothermic response induced by acute doses of 8-OH-DPAT in the rat
| Content Provider | Semantic Scholar |
|---|---|
| Author | Rényi, Lucy Möller, Kristina Ängeby Ensler, Katharina Evenden, John |
| Copyright Year | 1992 |
| Abstract | The effects of acute doses of 8-hydroxy 2-(di-n-dipropylamino)tetralin (8-OH-DPAT) on the hypothermic response, induced by a challenge dose of 8-OH-DPAT, were examined in rats. Acute doses of 8-OH-DPAT (1.0 or 0.5 mg/kg, s.c.) significantly attenuated the hypothermic response induced by 8-OH-DPAT (0.05 mg/kg, s.c.). The response to 8-OH-DPAT was almost abolished between 4 hr and 4 days and the attenuation of the response lasted for 21 days. On day 28 the response had returned to the control level. The non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, (+)-5-methyl-10,11-dihydro-5H-dibenzo-(a,d)cyclohepten-5,10-imine [(+)MK-801], blocked this long-lasting attenuation of the 8-OH-DPAT-induced hypothermic response. Given on its own, (+)MK-801 did not reduce body temperature, at the doses used in the experiments but the drug did block the acute effects of 8-OH-DPAT, at the same doses which blocked the attenuation of the hypothermic response. The present data suggest that stimulation of glutamate NMDA receptors may underlie the long-lasting effect of acute injections of 8-OH-DPAT. |
| Starting Page | 1265 |
| Ending Page | 1268 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0028-3908(92)90055-T |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/002839089290055T |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/002839089290055T?dgcid=api_sd_search-api-endpoint |
| PubMed reference number | 1470302 |
| Alternate Webpage(s) | https://doi.org/10.1016/0028-3908%2892%2990055-T |
| Journal | Medline |
| Volume Number | 31 |
| Journal | Neuropharmacology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
