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The effect of antidepressant drugs on the locomotor hyperactivity induced by MK-801, a non-competitive NMDA receptor antagonist
| Content Provider | Semantic Scholar |
|---|---|
| Author | Maj, Jerzy Rogóż, Zofia Skuza, Grażyna Sowińska, Helena |
| Copyright Year | 1992 |
| Abstract | It was found earlier that imipramine, amitriptyline and citalopram enhanced the locomotor hyperactivity induced by MK-801, a non-competitive NMDA receptor antagonist, in rats. Now, three other antidepressants: (+)-oxaprotiline, an inhibitor of the uptake of noradrenaline, (-)-oxaprotiline, an enantiomer devoid of any effect on the uptake of noradrenaline and fluoxetine, an inhibitor of the uptake of 5-hydroxytryptamine, have been examined in male Wistar rats. All those antidepressants, given in a single dose, increased the MK-801-induced locomotor hyperactivity. That increase was completely antagonized by haloperidol and partly by SCH 23390 and (+/-)-sulpiride; prazosin was inactive. Repeated administration of antidepressants produced a similar but more potent (than acute one) enhancement of the action of MK-801. Also, in that case haloperidol and SCH 23390 produced the strongest antagonistic effect; (+/-)-sulpiride and prazosin had a distinctly less potent action. Another effect of MK-801, anticonvulsant activity (electroshock-induced convulsions), was not increased by the antidepressants studied. These results indicate that antidepressants with a different pharmacological profile, increased the MK-801-induced locomotor hyperactivity, this effect being probably indirectly mediated, at least in part, by a dopamine mechanism. |
| Starting Page | 685 |
| Ending Page | 691 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0028-3908(92)90147-H |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/002839089290147H |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/002839089290147H?dgcid=api_sd_search-api-endpoint |
| PubMed reference number | 1407405 |
| Alternate Webpage(s) | https://doi.org/10.1016/0028-3908%2892%2990147-H |
| Journal | Medline |
| Volume Number | 31 |
| Journal | Neuropharmacology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
