NDLI: New synthetic benzisoxazole derivatives as antimicrobial, antioxidant and anti-inflammatory agents

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New synthetic benzisoxazole derivatives as antimicrobial, antioxidant and anti-inflammatory agents

Content Provider	Semantic Scholar
Author	Shivaprasad, Chalya Mallappaji Jagadish, Swamy Swaroop, Toreshettahally Ramesh Mohan, Chakrabhavi Dhananjaya Roopashree, Rangaswamy Kumar, Kothanahally S. Sharath Rangappa, Kanchugarakoppal Subbegowda
Copyright Year	2013
Abstract	A series of piperidine conjugated benzisoxazole derivatives were synthesized and evaluated for their antibacterial, anti-oxidant and anti-inflammatory activities. The results showed that most of the tested compounds exhibit good to moderate antimicrobial activity against some strains of Gram negative bacteria ( Escherichia coli , Klebsiella pneumoniae , Salmonella typhi , Shigella flexineri ) and Gram positive bacteria ( Bacillus subtilis ). Further, the molecules were evaluated for anti-oxidant assays such as DPPH scavenging, super oxide radical scavenging and hydroxyl radical scavenging assays. Most of the compounds showed potent antioxidant activities. Also, the synthesized compounds were screened for anti-inflammatory activities such as lipoxygenase inhibition and indirect haemolytic assays, where compounds revealed good activity.
Starting Page	402
Ending Page	407
Page Count	6
File Format	PDF HTM / HTML
DOI	10.5155/eurjchem.4.4.402-407.864
Volume Number	4
Alternate Webpage(s)	http://www.eurjchem.com/index.php/eurjchem/article/download/864/PDF
Alternate Webpage(s)	https://doi.org/10.5155/eurjchem.4.4.402-407.864
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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