NDLI: Synthesis and biological evaluation of new quinoxaline derivatives as antioxidant and anti-inflammatory agents.

Content Provider	Semantic Scholar
Author	Burguete, Asunción Pontiki, Eleni Hadjipavlou-Litina, Dimitra Ancizu, Saioa Villar, Raquel Solano, Beatriz Ramos Moreno, Elsa Torres, Enrique Pérez, Sílvia Pina Aldana, Ignacio Monge, Antonio
Copyright Year	2011
Abstract	We report the synthesis, anti-inflammatory, and antioxidant activities of novel quinoxaline and quinoxaline 1,4-di-N-oxide derivatives. Microwave-assisted methods have been used to optimize reaction times and to improve yields. The tested compounds presented important scavenging activities and promising in vitro inhibition of soybean lipoxygenase (LOX). Two of the best LOX inhibitors (compounds 7b and 8f) were evaluated as in vivo anti-inflammatory agents using the carrageenin-induced edema model. One of them (compound 7b) showed important in vivo anti-inflammatory effect (41%) similar to that of indomethacin (47%) used as the reference drug.
File Format	PDF HTM / HTML
DOI	10.1111/j.1747-0285.2011.01076.x
PubMed reference number	21244639
Journal	Medline
Volume Number	77
Issue Number	4
Alternate Webpage(s)	http://dadun.unav.edu/bitstream/10171/18591/3/ChemBiolDrugDes2011.pdf
Journal	Chemical biology & drug design
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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