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Three-way complex variant translocation involving short arm chromosome (1;9;22)(p36;q34;q11) in a chronic myeloid leukemia patient.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Asif, Muhammad Arsal Hussain, Abrar Malik, Arif Rasool, M. Imtiaz |
| Copyright Year | 2015 |
| Abstract | Chronic myeloid leukemia (CML) is a disease of the clonal hematopoietic stem cells caused by a balanced translocation between the long arms of chromosomes 9 and 22. Overall, 90-95% of CML patients present with a Philadelphia (Ph) chromosome t(9;22)(q34;q11) translocation and in addition, variant complex translocations, involving a third chromosome, are observed in 5-8% of CML patients. Cytogenic testing using bone marrow sample was performed and the FISH test was used for the detection of BCR-ABL fusion gene and complete blood analysis of CML patient was also performed. Results of hematological analysis showed the induced values of white blood cells (168,5000/mm3) and platelets (300,000/mm3) and FISH analysis test showed that 98% cells were positive for BCR/ABL gene translocation. The present study describes a three-way (1;9;22)(p36;q34;q11) Ph chromosome translocation in a 24-year-old female with CML. The patient, who was in the chronic phase of the disease, was treated with daily dose of 400 mg/dl with imatinib mesylateand was monitored constantly at various intervals over a 6-month period. Many studies reported that certain CML patents with variant translocation responded poorly to imatinib. In the current case report, the CML patient exhibited a suboptimal response to imatinib, denoting a poor prognosis. |
| Starting Page | 1728 |
| Ending Page | 1730 |
| Page Count | 3 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.spandidospublications.com/ol/10/3/1728/download |
| PubMed reference number | 26622740v1 |
| Volume Number | 10 |
| Issue Number | 3 |
| Journal | Oncology letters |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Alveolar rhabdomyosarcoma Bone Marrow Chromosomal translocation Chromosomes Clone Fusion Proteins, bcr-abl Hematopoietic stem cells International Normalized Ratio Legal patent Leukemia, B-Cell Leukocytes Myeloid Leukemia Myeloid Leukemia, Chronic Patients Platelet Count measurement imatinib |
| Content Type | Text |
| Resource Type | Article |
