NDLI: Chronic neutrophilic leukaemia: 14 new cases of an uncommon myeloproliferative disease.

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Chronic neutrophilic leukaemia: 14 new cases of an uncommon myeloproliferative disease.

Content Provider	Semantic Scholar
Author	Boehm, Joachim Schaefer, Hans Eckart
Copyright Year	2002
Abstract	BACKGROUND Chronic neutrophilic leukaemia (CNL) is a distinct BCR/ABL negative myeloproliferative disorder of elderly patients characterised by sustained neutrophilia and splenomegaly. The bone marrow shows expansion of neutrophilic granulopoiesis, without excess of myeloblasts. To date, only 129 cases of CNL have been reported in the literature. AIMS To report the findings from a large group of 14 new cases of CNL, consisting of eight women and six men (mean age, 64.7 years). METHODS A review of the 14 new cases of CNL and the investigation of BCR/ABL translocations in these patients. RESULTS Three quarters of the patients died within two years after diagnosis, mostly as a result of severe cerebral haemorrhage. Two younger patients were successfully treated with allogeneic bone marrow transplantation or interferon, which resulted in haematological remission for years. CONCLUSION CNL is a rare myeloproliferative disease mostly taking a fatal clinical course, despite the presence of mature neutrophils as leukaemic cells in the blood. Thus, it is important to recognise CNL to develop appropriate therapeutic strategies for affected patients.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://jcp.bmj.com/content/jclinpath/55/11/862.full.pdf
PubMed reference number	12401827v1
Volume Number	55
Issue Number	11
Journal	Journal of clinical pathology
Language	English
Access Restriction	Open
Subject Keyword	Abetalipoproteinemia Cessation of life Chromosomal translocation Chronic Neutrophilic Leukemia Fusion Proteins, bcr-abl Granulocyte differentiation Hemorrhage International Normalized Ratio Leukemia, Myeloid, Chronic-Phase Myeloblast count procedure Myeloid Leukemia Myeloproliferative disease Patients Sweet Syndrome abl Oncogene allogeneic bone marrow transplantation
Content Type	Text
Resource Type	Article

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