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Analysis of the fragile histidine triad (FHIT) gene in lobular breast cancer.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Huiping, Chen Jónasson, Jón Gunnlaugur Agnarsson, Bjarni Agnar Sigbjornsdottir, Bjarnveig I. Huebner, Kay F. Ingvarsson, Sigurður |
| Copyright Year | 2000 |
| Abstract | The fragile histidine triad (FHIT) gene is a candidate tumour suppressor gene in breast and other cancers. We investigated deletions within the FHIT gene in lobular breast cancer and found that 16% of cases showed loss of heterozygosity (LOH) within the gene. We compared LOH within FHIT in lobular and ductal breast tumours and found a significant association between LOH at FHIT and the ductal histological type (P<0.001). To determine whether genomic alteration of the FHIT gene in lobular breast cancer leads to Fhit inactivation we have assessed the level of Fhit expression by immunohistochemical detection and determined that 27% (15 of 55) consecutive sporadic lobular tumours showed negative or reduced Fhit expression. A significant association was found between LOH at the FHIT gene and reduced Fhit expression in lobular and ductal tumours (P=0.025 and P=0.001, respectively). Thus, genetic alterations within the FHIT gene, leading to loss of Fhit protein, may play an important role in the carcinogenesis of a significant number of sporadic lobular breast cancers, even though the apparent frequency of genomic alterations within the gene is lower than in ductal breast cancer. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://skemman.is/stream/get/1946/21751/50584/1/Chen2000EJCfhit.pdf |
| PubMed reference number | 10930803v1 |
| Volume Number | 36 |
| Issue Number | 12 |
| Journal | European journal of cancer |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Carcinogenesis Ductal Breast Carcinoma In Situ and Lobular Carcinoma In Situ FHIT gene FHIT protein, human Heterozygote Histidine Loss of Heterozygosity Malignant Neoplasms Mammary Ductal Carcinoma Mammary Neoplasms |
| Content Type | Text |
| Resource Type | Article |
