NDLI: IRS2 mutations linked to invasion in pleomorphic invasive lobular carcinoma.

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IRS2 mutations linked to invasion in pleomorphic invasive lobular carcinoma.

Content Provider	Semantic Scholar
Author	Zhu, Sha Ward, Brian M. Yu, Jun Matthew-Onabanjo, Asia N. Janusis, Jenny Hsieh, Chung-Cheng Tomaszewicz, Keith Hutchinson, Lloyd Zhu, Lihua Julie Kandil, Dina M. Shaw, L. M. Morrie
Copyright Year	2018
Abstract	Pleomorphic invasive lobular carcinoma (PILC) is an aggressive variant of invasive lobular breast cancer that is associated with poor clinical outcomes. Limited molecular data are available to explain the mechanistic basis for PILC behavior. To address this issue, targeted sequencing was performed to identify molecular alterations that define PILC. This sequencing analysis identified genes that distinguish PILC from classic ILC and invasive ductal carcinoma by the incidence of their genomic changes. In particular, insulin receptor substrate 2 (IRS2) is recurrently mutated in PILC, and pathway analysis reveals a role for the insulin receptor (IR)/insulin-like growth factor-1 receptor (IGF1R)/IRS2 signaling pathway in PILC. IRS2 mutations identified in PILC enhance invasion, revealing a role for this signaling adaptor in the aggressive nature of PILC.
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=4458&context=oapubs
PubMed reference number	29669935v1
Alternate Webpage(s)	https://doi.org/10.1172/jci.insight.97398
DOI	10.1172/jci.insight.97398
Journal	JCI insight
Volume Number	3
Issue Number	8
Language	English
Access Restriction	Open
Subject Keyword	Biopolymer Sequencing CCL27 gene Carcinoma, Lobular IGF2R protein, human INSR protein, human IRS2 gene IRS2 protein, human Invasive Ductal Breast Carcinoma Invasive Lobular Breast Carcinoma Lobular carcinoma in situ of breast Mammary Neoplasms Mutation Signal Transduction
Content Type	Text
Resource Type	Article

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