Loading...
Please wait, while we are loading the content...
Similar Documents
Differentiation of tumours of ductal and lobular origin: I. Proteomics of invasive ductal and lobular breast carcinomas.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Turashvili, Gulisa Bouchal, Jan Burkadze, George Kolář, Zdeněk |
| Copyright Year | 2005 |
| Abstract | The vast majority of invasive breast tumors are ductal and lobular breast carcinomas. Despite the many similarities, some clinical follow-up data and the patterns of metastases suggest that these histological subtypes of breast cancer are biologically distinct. Few papers, however, describe immunohistochemical markers useful for differentiation of these carcinomas. Many investigations suggest that E cadherin protein expression is lost in lobular but not in ductal carcinoma. The absence of E-CD, as a partial loss of epithelial differentiation, may account for the extended spread of lobular carcinoma in situ and the peculiar diffuse invasion mode of invasive lobular carcinoma. Some investigations report the significance of E-CD associated proteins alpha-, beta-, gamma-catenin expression, as well as the usefulness of cytokeratins 5, 6, 8, 7 and thrombospondin in differentiating histological types of breast invasive carcinomas. Several reports have suggested the possibility that invasive ductal and lobular cancers differ with respect to expression of antigens involved in proliferation and cell cycle regulation. It has been shown that vascular endothelial growth factor expression, also the expression of maspin, a tumour suppressor gene product, is higher in ductal, than in lobular carcinoma. Expression of NKX3.1, a member of the NK-class of homeodomain, is highly restricted and is found primarily in lobular carcinoma. Some histological and immunohistochemical characteristics of pleomorphic lobular carcinoma are also discussed. |
| Starting Page | 57 |
| Ending Page | 62 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://biomed.papers.upol.cz/pdfs/bio/2005/01/06.pdf |
| Alternate Webpage(s) | http://publib.upol.cz/~obd/fulltext/Biomedpapers149-1/BiomedPapers149-1-05.pdf |
| Alternate Webpage(s) | http://biomed.papers.upol.cz/savepdfs/bio/2005/01/05.pdf |
| Alternate Webpage(s) | http://publib.upol.cz/~obd/fulltext/Biomedpapers149-1/BiomedPapers149-1-06.pdf |
| PubMed reference number | 16170389v1 |
| Volume Number | 149 |
| Issue Number | 1 |
| Journal | Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Cadherins Carcinoma, Lobular Catenins Cell Cycle Control Cell Differentiation process Cytokeratin Ductal Breast Carcinoma In Situ and Lobular Carcinoma In Situ Endothelial Growth Factors Genome Encoded Entity Growth Factor Invasive Lobular Breast Carcinoma Lobular carcinoma in situ of breast Malignant Neoplasms Mammary Neoplasms Paper Proteomics SERPINB5 gene Sensorineural Hearing Loss (disorder) Subtype (attribute) Thrombospondins plakoglobin |
| Content Type | Text |
| Resource Type | Article |
