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eview he role of DNA damage and repair in aging through the prism of och-like criteria
| Content Provider | Semantic Scholar |
|---|---|
| Author | Moskaleva, L. A. Shaposhnikova, M. V. Plyusninaa, Ekaterina N. Zhavoronkovb, Lex Budovskyd, Arie Yanaie, Hagai Fraifelde, Vadim E. |
| Copyright Year | 2012 |
| Abstract | Since the first publication on Somatic Mutation Theory of Aging (Szilárd, 1959), a great volume of knowledge in the field has been accumulated. Here we attempted to organize the evidence “for” and “against” the hypothesized causal role of DNA damage and mutation accumulation in aging in light of four Kochlike criteria. They are based on the assumption that some quantitative relationship between the levels of DNA damage/mutations and aging rate should exist, so that (i) the longer-lived individuals or species |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.aging-genes.ru/images/all/arr2012_2.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |