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eview he crucial impact of lysosomes in aging and longevity
| Content Provider | Semantic Scholar |
|---|---|
| Author | Carmona-Gutierreza, Idac Hughesb, Adam L. Madeoa, Frank Ruckenstuhla, Hristoph |
| Copyright Year | 2016 |
| Abstract | Lysosomes are the main catabolic organelles of a cell and play a pivotal role in a plethora of cellular processes, including responses to nutrient availability and composition, stress resistance, programmed cell death, plasma membrane repair, development, and cell differentiation. In line with this pleiotropic importance for cellular and organismal life and death, lysosomal dysfunction is associated with many age-related pathologies like Parkinson’s and Alzheimer’s disease, as well as with a decline in lifespan. Conversely, targeting lysosomal functional capacity is emerging as a means to promote longevity. Here, we analyze the current knowledge on the prominent influence of lysosomes on aging-related processes, such as their executory and regulatory roles during general and selective macroautophagy, or their stor- |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://static1.squarespace.com/static/57b4ad9903596e4010f96e16/t/5c09b5f52b6a28d102dd98a1/1544140279456/The+crucial+impact+of+lysosomes.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
