NDLI: The role of DNA damage and repair in aging: New approaches to an old problem

Content Provider	Semantic Scholar
Author	Vijg, Jan
Copyright Year	2008
Abstract	DNA damage and mutations have been implicated as key causal events in the biological process of aging. In this context, it has been hypothesized that the complex of genome maintenance systems acts as a longevity assurance system by signaling and repairing damage or removing cells that are beyond repair. In the past, various approaches have been taken to clarify the importance of preserving genome integrity for healthy aging. Here I will briefly review these approaches in the context of the progress made in improving our understanding of the interrelationship between DNA damage, genome maintenance and mutations.
Starting Page	498
Ending Page	502
Page Count	5
File Format	PDF HTM / HTML
DOI	10.1016/j.mad.2008.02.009
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0047637408000511
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0047637408000511?dgcid=api_sd_search-api-endpoint
PubMed reference number	18394680
Alternate Webpage(s)	https://doi.org/10.1016/j.mad.2008.02.009
Journal	Medline
Volume Number	129
Journal	Mechanisms of Ageing and Development
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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