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The role of inducible nitric oxide synthase in macrophage activation following acute lung injury
| Content Provider | Semantic Scholar |
|---|---|
| Author | Golden, Thea |
| Copyright Year | 2016 |
| Abstract | OF DISSERTATION ...................................................................................ii ACKNOWLEDGEMENTS ..............................................................................................iv ACKNOWLEDGEMENT OF PUBLICATIONS ..............................................................vii LIST OF FIGURES ..........................................................................................................x LIST OF TABLES .........................................................................................................xii CHAPTER 1: BACKGROUND ........................................................................................1 1.1 Pulmonary Innate Immunity ................................................................................1 1.2 Recruitment ..........................................................................................................3 1.3 Macrophage Differentiation and Activation ........................................................5 1.4 Nitric Oxide Physiology .......................................................................................8 1.5 Clinical Acute Lung Injury Pathology .................................................................9 1.6 Treatment of Acute Lung Injury ........................................................................11 1.7 Models of Acute Lung Injury .............................................................................13 CHAPTER 2: TOCOPHEROL SUPPLEMENTATION REDUCES NO PRODUCTION AND PULMONARY INFLAMMATORY RESPONSE TO BLEOMYCIN ........................15 2.1 Abstract ..............................................................................................................15 2.2 Introduction ........................................................................................................16 2.3 Methods ..............................................................................................................18 2.4 Results ................................................................................................................22 2.5 Discussion ..........................................................................................................26 2.6 Tables .................................................................................................................31 2.7 Figures ................................................................................................................35 CHAPTER 3: INDUCIBLE NITRIC OXIDE SYNTHASE ROLE IN MACROPHAGE RECRUITMENT AND POLARIZATION IN ACUTE LUNG INJURY ..............................44 3.1 Abstract ..............................................................................................................44 3.2 Introduction ........................................................................................................44 3.3 Methods ..............................................................................................................46 3.4 Results ................................................................................................................49 3.5 Discussion ..........................................................................................................54 3.6 Tables .................................................................................................................57 3.7 Figures ................................................................................................................60 CHAPTER 4: ORIGIN OF INOS DETERMINES EFFECT ON MACROPHAGE ACTIVATION IN ACUTE LUNG INJURY ......................................................................69 4.1 Abstract ..............................................................................................................69 4.2 Introduction ........................................................................................................69 4.3 Methods ..............................................................................................................71 4.4 Results ................................................................................................................72 4.5 Discussion ..........................................................................................................75 4.6 Tables .................................................................................................................77 4.7 Figures ................................................................................................................79 CHAPTER 5: SUMMARY, DISCUSSION AND CONCLUSION ....................................84 |
| File Format | PDF HTM / HTML |
| DOI | 10.7282/T3HM5BRV |
| Alternate Webpage(s) | https://rucore.libraries.rutgers.edu/rutgers-lib/51297/PDF/1/play/ |
| Alternate Webpage(s) | https://doi.org/10.7282/T3HM5BRV |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
