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ONO-1714, a Nitric Oxide Synthase Inhibitor, Attenuates Endotoxin-Induced Acute Lung Injury in Rabbits
| Content Provider | CiteSeerX |
|---|---|
| Author | Mikawa, Katsuya |
| Abstract | Overproduction of nitric oxide by inducible nitric oxide synthase (iNOS) expressed in the lung is thought to play a crucial role in the pathogenesis of endotoxininduced acute lung injury (ALI). In this two-part study, we determined whether ONO-1714, a new selective iNOS inhibitor, attenuates endotoxin-induced ALI in rabbits. For Part I of the study, a control group received IV saline and ALI was induced by IV infusion of endotoxin 5 mg/kg over 30 min in 4 groups. Three groups received either 0.1, 0.03, or 0.01 mg/kg of ONO-1714 10 min before the start of endotoxin and the fourth group received saline. For Part II of the study, ALI was induced by endotoxin infusion in all 6 groups. One group was treated with saline. The other 5 groups received ONO-1714 0.1 mg/kg at various timings (10 min |
| File Format | |
| Access Restriction | Open |
| Subject Keyword | Nitric Oxide Synthase Inhibitor Endotoxininduced Acute Lung Injury Fourth Group Iv Infusion Nitric Oxide Attenuates Endotoxin-induced Acute Lung Injury Two-part Study Various Timing New Selective Inos Inhibitor Iv Saline Inducible Nitric Oxide Synthase Crucial Role Endotoxin Infusion Part Ii Endotoxin-induced Ali |
| Content Type | Text |
