NDLI: Rapid activation of the novel serine/threonine protein kinase, protein kinase D by phorbol esters, angiotensin II and PDGF-BB in vascular smooth muscle cells.

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Rapid activation of the novel serine/threonine protein kinase, protein kinase D by phorbol esters, angiotensin II and PDGF-BB in vascular smooth muscle cells.

Content Provider	Semantic Scholar
Author	Abedi, Husna Rozengurt, Enrique
Copyright Year	1998
Abstract	Protein kinase D (PKD) is a novel serine/threonine kinase structurally distinct from all protein kinase C (PKC) isoforms but which like classic and novel PKCs is activated by phorbol esters and diacylglycerol. This study investigated the regulation of PKD in vascular smooth muscle cells (VSMC) by physiological regulators of VSMC function and growth factors. Treatment of rabbit aortic VSMC with phorbol ester, angiotensin II and PDGF-BB all stimulated PKD activity in a time- and concentration-dependent manner in VSMC. The effect of angiotensin II was particularly rapid and potent (maximum stimulation within 1 min and at 0.5 nM). In contrast, the maximum effect of PDGF-BB was obtained after 5 min. Other factors, including basic FGF, IGF-I, IGF-II, endothelin-1 and endothelin-2, had no effect on PKD activity in VSMC. These results show for the first time that PKD activity is regulated in VSMC, and is activated by the vasoconstrictor angiotensin II. PKD may be an important mediator for the biological function(s) of one or more PKC isoforms in VSMC and/or may represent a component of a novel PKC-independent signalling pathway in VSMC.
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://core.ac.uk/download/pdf/82774626.pdf
PubMed reference number	9607313v1
Volume Number	427
Issue Number	2
Journal	FEBS letters
Language	English
Access Restriction	Open
Subject Keyword	1,2-diacylglycerol Angiotensin II Angiotensins Aortic Valve Insufficiency Becaplermin Endothelin-1 Endothelin-2 Fibroblast Growth Factor Insulin-Like Growth Factor I MARK2 gene Mediator of activation protein Muscle Cells Muscle, Smooth, Vascular Myocytes, Smooth Muscle Phorbol Esters Phorbols Protein Isoforms Protein Kinase C Protein Kinases Protein-Serine-Threonine Kinases Signal Transduction Smooth muscle (tissue) Somatomedins Threonine biological signaling
Content Type	Text
Resource Type	Article

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