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Modulation of elastin expression and cell proliferation in vascular smooth muscle cells in vitro.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Tajima, Shingo |
| Copyright Year | 1996 |
| Abstract | Elastin expression in cultured vascular smooth muscle cell (VSMC) was found to be enhanced by potent inhibitors of VSMC proliferation including minoxidil, heparin and retinoic acid. By contrast, elastin expression was declined by potent stimulators of VSMC proliferation like epidermal growth factor, high K+, angiotension II and phorbol ester. To elucidate the relationship between elastin expression and cell proliferation, the elastin expression in the different cell growth states brought by cell-synchronizing culture or suspension culture, a culture system independent of potent modulators of VSMC proliferation. Elastin was found to be expressed maximally at G0 and minimally at G2/M phases, suggesting that cell growth state regulates elastin expression in VSMC culture. Synthetic elastin peptide VPGVG or its polymeric form (VPGVG)n enhanced VSMC proliferation, which resulted in the reduction of elastin expression. The results suggests that elastin fragment regulates VSMC proliferation. These correlation between elastin expression and cell growth state may play an essential role in elastin metabolism under the normal and diseased conditions. |
| Starting Page | 58 |
| Ending Page | 62 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.jstage.jst.go.jp/article/kjm1952/45/1/45_1_58/_pdf/-char/en |
| PubMed reference number | 8882470v1 |
| Volume Number | 45 |
| Issue Number | 1 |
| Journal | The Keio journal of medicine |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Angiotensin II Cell Proliferation Growth Factor Minoxidil Muscle Cells Muscle, Smooth, Vascular Myocytes, Smooth Muscle Phorbol Esters Phorbols Polymers Smooth muscle (tissue) Suspension Culture Suspension substance Tretinoin Vascular smooth muscle cell cell growth elastin metabolic process heparin valyl-prolyl-glycyl-valyl-glycine |
| Content Type | Text |
| Resource Type | Article |
