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Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes
| Content Provider | Semantic Scholar |
|---|---|
| Author | Killeen, Nigel Weiss, Angela |
| Copyright Year | 1996 |
| Abstract | The Src-family and Syk/ZAP-70 family of protein tyrosine kinases (PTK) are required for T cell receptor (TCR) functions. We provide evidence that the Src-family PTK Lck is responsible for regulating the constitutive tyrosine phosphorylation of the TCR zeta subunit in murine thymocytes. Moreover, ligation of the TCR expressed on thymocytes from Lck-deficient mice largely failed to induce the phosphorylation of TCR-zeta, CD3 epsilon, or ZAP-70. In contrast, we find that the TCR-zeta subunit is weakly constitutively tyrosine phosphorylated in peripheral T cells isolated from Lck-null mice. These data suggest that Lck has a functional role in regulation of TCR signal transduction in thymocytes. In peripheral T cells, other Src-family PTKs such as Fyn may partially compensate for the absence of Lck. |
| Starting Page | 1053 |
| Ending Page | 1062 |
| Page Count | 10 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 8642247 |
| Volume Number | 183 |
| Journal | The Journal of experimental medicine |
| Alternate Webpage(s) | http://jem.rupress.org/content/jem/183/3/1053.full.pdf |
| Alternate Webpage(s) | http://ftp.ncbi.nlm.nih.gov/pub/pmc/11/4e/je18331053.PMC2192313.pdf |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Leukemia, B-Cell Ligation Protein Tyrosine Kinase Signal Transduction T-Cell Receptor T-Lymphocyte Tyrosine Phosphorylation thymocyte |
| Content Type | Text |
| Resource Type | Article |
