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Association of tyrosine protein kinase Zap-70 with the protooncogene product p120c-cbl in T lymphocytes
| Content Provider | Semantic Scholar |
|---|---|
| Author | Fournel, Marielle Davidson, Dominique Weil, Robert Veillette, André |
| Copyright Year | 1996 |
| Abstract | Accumulating data show that the tyrosine protein kinase Zap-70 plays an essential role in T cell receptor-mediated signal transduction. However, the model of action, as well as the physiologically relevant substrates of Zap-70, have not been determined. We have attempted to identify a 120-kD tyrosine-phosphorylated protein (p120) that associates with Zap-70 in activated T lymphocytes. The results of our analyses showed that p120 is largely encoded by the c-cbl protooncogene. Furthermore, the association of Zap-70 with c-Cbl was shown to be induced by T cell receptor stimulation, implying that it required posttranslational modification of one or both of these products. FynT, but not Lck, also associated with c-Cbl in activated T cells. Finally, using a heterologous system, it was demonstrated that the ability of Zap-70 to cause tyrosine phosphorylation of p120c-cbl was dependent on Lck- or FynT-mediated signals. As c-Cbl can associate with several other signaling molecules, it may couple Zap-70 to downstream effectors during T cell activation. |
| Starting Page | 301 |
| Ending Page | 306 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 8551236 |
| Volume Number | 183 |
| Journal | The Journal of experimental medicine |
| Alternate Webpage(s) | http://ftp.ncbi.nlm.nih.gov/pub/pmc/72/f5/je1831301.PMC2192430.pdf |
| Alternate Webpage(s) | http://jem.rupress.org/content/jem/183/1/301.full.pdf |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Attempt CBL gene CBL wt Allele CD4 Positive T Lymphocytes CTNND1 wt Allele Chronic Lymphocytic Leukemia Helper-Inducer T-Lymphocyte Leukemia, B-Cell Post-Translational Protein Processing Protein Kinases Protein Tyrosine Kinase Proto-Oncogenes Signal Transduction Tyrosine Phosphorylation ZAP70 gene ZAP70 protein, human ZAP70 wt Allele |
| Content Type | Text |
| Resource Type | Article |
