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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Dragone, Leonard L. Weiss, Arthur Myers, Margaret D. |
| Description | Author Affiliation: Myers MD ( Department of Medicine, Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco, CA 94143, USA.) |
| Abstract | Src-like adaptor protein (SLAP) down-regulates expression of the T cell receptor (TCR)–CD3 complex during a specific stage of thymocyte development when the TCR repertoire is selected. Consequently, SLAP−/− thymocytes display alterations in thymocyte development. Here, we have studied the mechanism of SLAP function. We demonstrate that SLAP-deficient thymocytes have increased TCRζ chain expression as a result of a defect in TCRζ degradation. Failure to degrade TCRζ leads to an increased pool of fully assembled TCR–CD3 complexes that are capable of recycling back to the cell surface. We also provide evidence that SLAP functions in a pathway that requires the phosphorylated TCRζ chain and the Src family kinase Lck, but not ZAP-70 (ζ-associated protein of 70 kD). These studies reveal a unique mechanism by which SLAP contributes to the regulation of TCR expression during a distinct stage of thymocyte development. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 2 |
| Volume Number | 170 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 2005-07-18 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Membrane Proteins Biosynthesis Proto-Oncogene Proteins Pp60(c-src) Metabolism Receptor-CD3 Complex, Antigen, T-Cell Receptors, Antigen, T-Cell T-Lymphocytes Physiology Animals Cell Line, Tumor Down-Regulation Lymphocyte Specific Protein Tyrosine Kinase P56(lck) Genetics Mice Mice, Inbred C57BL Mice, Knockout Phosphorylation Protein Binding Protein-Tyrosine Kinases Signal Transduction ZAP-70 Protein-Tyrosine Kinase Src Homology Domains Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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