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Phenylalanine 445 within oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae influences C-Ring cyclization and deprotonation reactions.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Wu, Tung-Kung Liu, Yuan-Ting Chiu, Feng-Hsuan Chang, C. |
| Copyright Year | 2006 |
| Abstract | [reaction: see text] We describe the Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase Phe445 site-saturated mutants that generate truncated tricyclic and altered deprotonation product profiles. Among these mutants, only polar side-chain group substitutions genetically complemented yeast viability and produced spatially related product diversity, supporting the Johnson model that cation-pi interactions between a carbocationic intermediate and an enzyme can be replaced by an electrostatic or polar side chain to stabilize the cationic intermediate, but with product differentiation. |
| File Format | PDF HTM / HTML |
| DOI | 10.1021/ol061549r |
| PubMed reference number | 17020279 |
| Journal | Medline |
| Volume Number | 8 |
| Issue Number | 21 |
| Alternate Webpage(s) | http://life.nctu.edu.tw/~tkwu/paper/%5Bwu-6%5D%20Phenylalanine%20445%20within.pdf |
| Alternate Webpage(s) | https://ir.nctu.edu.tw/bitstream/11536/11677/1/000241030900006.pdf |
| Alternate Webpage(s) | http://www.qmclab.com/labwiki/files/literature/terpene/triterpene/Oxidosqualene%20Cyclase/mutation%20of%20ERG7/(2006%20Org.%20Lett.%20Tung-Kung%20Wu%20)+ERG7%20(Phe445%20mutant)%20.pdf |
| Alternate Webpage(s) | https://doi.org/10.1021/ol061549r |
| Journal | Organic letters |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
